Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lithium | after inhibition of GSK-3 in cortical neurons, the splicing factor SC35 is nuclearly redistributed and enriched in nuclear speckles and colocalizes with the kinase | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microtubule | - |
Homo sapiens | 5874 | - |
nucleus | GSK-3 after cell treatment with lithium | Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + SC35 | Homo sapiens | substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors | ADP + phosphorylated SC35 | - |
? | |
ATP + [tau-protein] | Homo sapiens | - |
ADP + O-phospho-[tau-protein] | - |
? | |
additional information | Homo sapiens | GSK-3 affects the tau-mRNA splicing of exon 10 via phosphorylation of the splicing factors of the serine/arginine-rich splicing factor SR family, e.g. SC35, leading to priming and dislocation of the splicing factor, aberrant tau splicing contributes to tauopathies including Alzheimer's disease, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain cortex | - |
Homo sapiens | - |
commercial preparation | purified recombinant GSK-3beta | Homo sapiens | - |
neuron | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RSRSRSRSRSRSPPPVSK | SC35-derived peptide 180-197, recombinant GSK-3beta | Homo sapiens | ADP + phosphorylated RSRSRSRSRSRSPPPVSK | - |
? | |
ATP + SC35 | substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors | Homo sapiens | ADP + phosphorylated SC35 | - |
? | |
ATP + SC35 | substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors, recombinant GSK-3beta | Homo sapiens | ADP + phosphorylated SC35 | - |
? | |
ATP + [tau-protein] | - |
Homo sapiens | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | substrate of GSK-3 in brain | Homo sapiens | ADP + O-phospho-[tau-protein] | - |
? | |
additional information | GSK-3 affects the tau-mRNA splicing of exon 10 via phosphorylation of the splicing factors of the serine/arginine-rich splicing factor SR family, e.g. SC35, leading to priming and dislocation of the splicing factor, aberrant tau splicing contributes to tauopathies including Alzheimer's disease, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3 | - |
Homo sapiens |
GSK-3 | - |
Homo sapiens |
GSK-3beta | - |
Homo sapiens |
More | see also EC 2.7.11.26 | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |